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Valproic acid/valproate: interaction with carbapenem
2010.06.17
Active substance: valproic acid
The product information texts on all valproic acid or products containing valproates should include warnings about clinically relevant interactions with carbapenems (decreased valproate plasma concentration) to come up to the latest findings. The intended measures are due to an EU recommendation. A hearing in writing under the graduated plan procedure (Stufenplan), stage II, will follow.
To the graduated plan procedure (available in German only)